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What Size Thyroid Nodule Should Be Biopsied

Thyroid Nodules Are Usually Benign And Not Cancerous

Nodule size and malignancy. In Thyroid.

The good news is that most people with thyroid nodules do not and will not get thyroid cancer.

The bad news is that a thyroid nodule is not normal and may be associated with other conditions of your thyroid gland.

So, even if you don’t have thyroid cancer, you should still have your thyroid nodule evaluated and tested for other conditions which are associated with thyroid nodules.

Conditions in this category include:

It’s important to realize that many thyroid nodules are just run-of-the-mill nodules which are not associated with thyroid disease of any kind.

But, in order to be on the safe side, it’s ideal that every patient who has a thyroid nodule undergoes certain tests to ensure that this is the case.

Tests such as a comprehensive history and physical, palpation of the thyroid gland, tests of your thyroid function through blood work, and even an ultrasound may all be warranted.

Your doctor should be walking you through these steps but you can also ask for them if you are worried.

Key Issues In Goiter & Thyroid Nodule

Whenever a person has a goiter or thyroid nodule, three questions must be answered.

  • Is the gland, or a portion of it, so large that it is stretching, compressing, or invading nearby structures? Thyroid swelling can cause a sensation of tightness or, less commonly, pain in the front of the neck. A goiter or nodule can compress the windpipe causing cough or shortness of breath, while pressure on the swallowing tube can cause discomfort with swallowing or even the inability to get things down. When a goiter extends down into the chest, blood returning from the neck and head can be partially obstructed, causing neck veins to bulge. When a goiter or nodule is due to cancer, the tumor may actually grow into nearby structures, causing pain, hoarseness when nerves to the voice box are invaded, or coughing up blood when the trachea is penetrated.
  • Third, is the goiter or thyroid nodule due to malignancy? Fortunately, most patients with a goiter or thyroid nodule do not have thyroid cancer. Often other findings in a patient with a goiter, such as the features of hyperthyroid Graves disease, make it unnecessary to do additional tests to rule out cancer. On the other hand, almost everyone with a thyroid nodule larger than 1.0 to 1.5 cm in diameter must be investigated for the possibility of thyroid cancer. The approach to these diagnostic evaluations is discussed below.
  • Table 2. Key Issues to Evaluate in a Person with a Goiter or Thyroid Nodule

    Do I Need A Biopsy Or Surgery For My Thyroid Nodule

    Jul 17, 2018 | Head and Neck, Your Health

    Thyroid nodules are very common. These masses within the thyroid gland are composed of tissue and/or fluid and are estimated to be present in more than 50 percent of those aged 50 and older. Nodules can run in families, are more common in women, and increase in frequency with age.

    Patients diagnosed with a thyroid nodule often ask if their nodule needs to be biopsied or surgically removed. Sometimes the answer is yes, but often the answer depends on a number of patient and nodule-related factors. Catherine Sinclair, MD, FRACS, head and neck surgeon at Mount Sinai West, explains why your nodule may, or may not, need special attention.

    How do you know if you need a biopsy?

    More than 95 percent of thyroid nodules are non-cancerous, although a family history of thyroid cancer in a first-degree relative or whole-body/neck/chest radiation exposure may increase the risk. Nodules have a low cancer risk, so whether to biopsy depends on the size and ultrasound appearance of the mass.

    How is risk measured?

    What are the symptoms and treatment for thyroid nodules?

    In summary, a thyroid nodule may require an operation if there is a high risk of the nodule being cancerous or if the non-cancerous nodule is large and causing symptoms.

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    Thyroid Nodule Biopsy: Cancer Of Thyroid Nodules Is Diagnosed By Fine Needle Aspiration Biopsy

  • FNA is an abbreviation for Fine Needle Aspiration Biopsy. This is a common test performed thousands of times per day on people with thyroid nodules.
  • FNA is a type of biopsy. A biopsy is the removal of some cells from the body so they can be looked at under a microscope to see if the cells are cancerous.
  • The only purpose of a FNA biopsy is to get cells from the thyroid to look at under a microscope. If not enough cells are removed, the test is worthless or not diagnostic .
  • Thus, FNA is used to diagnose thyroid cancer in a patient with a thyroid nodule that is suspicious for cancer .
  • FNA biopsy can also be done on lymph nodes in the neck which are around the thyroid to see if there are any thyroid cancer cells inside the lymph nodes.
  • Ultrasound allows the doctors to see the thyroid nodule or lymph node during the needle biopsy, which helps make sure they are getting the needle stuck into the right areas.
  • FNA biopsy is the same as: needle biopsy of thyroid, FNA needle biopsy, FNA of thyroid, etc. They are all the same thing so don’t be confused.
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    The Epidemic of Thyroid Nodules: Which Should Undergo Fine ... is an educational service of the Clayman Thyroid Center, the worlds leading thyroid cancer surgery center.

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    Thyroid Nodules And Thyroid Cancer

    The biggest concern on most people’s mind is probably whether or not their thyroid nodule is actually cancer in disguise.

    As I mentioned previously, most thyroid nodules are benign.

    But that leaves another 5-10% which can be cancerous and should be evaluated.

    There are some factors which have been evaluated which can help you understand your risk of thyroid cancer.

    The risk of thyroid cancers increases with these risk factors:

    Ultrasound Testing & Manual Exams

    There are really three different ways to test or evaluate your thyroid nodule.

    The first is with a manual exam, usually performed by your doctor.

    This is an easy way to test whether or not you need further testing.

    Your doctor can do this when you visit him/her in the office.

    This test is usually done by manually feeling or palpating the thyroid gland while the patient is taking a drink of water.

    The second is with ultrasound testing, usually performed by an ultrasound technician and read by a radiologist.

    Ultrasound testing can help you to understand if your thyroid nodule looks suspicious or not.

    There are certain factors, or characteristics, which, if present, may increase your risk of having thyroid cancer.

    These factors include:

    • The presence of absence of calcificationMicrocalcifications found within thyroid nodules may suggest the presence of thyroid cancer.
    • The shape of the nodule – If your thyroid nodule is taller than it is wide then that is a risk factor for thyroid cancer.
    • The vascularity of the nodule – The presence of vascularity by Doppler ultrasound is also suspicious for thyroid cancer.
    • The margins of the nodule – Nodules which have irregular borders, which look ‘infiltrative’ , or which have speculated margins are all suspicious.

    Your ultrasound report should include this information and you can request this information from your primary care doctor or your radiologist.

    The third is with a biopsy, usually guided by an ultrasound.

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    What Will A Biopsy Tell Me

    Sometimes, a nodule or goiter just sits there and isnât dangerous.

    When they do cause problems, it could be something like:

    Cysts, fluid-filled nodules that can give you neck pain or make it hard to swallow. Theyâre very rarely cancer but still might need treatment.

    Gravesâ disease, which causes your thyroid to grow and make too many hormones.

    Hashimotoâs disease, where your thyroid is damaged by your immune system, so it makes fewer hormones than normal and then swells.

    Infection, where a virus causes pain and swelling in your thyroid.

    Large nodules or goiters that are an issue because of their size. They can push into surrounding body parts and make it harder to breathe or swallow.

    Toxic nodules or goiters, which are almost never cancer, can cause your thyroid to pump out too many hormones.

    Cancer, which makes up about 10% of cases.

    Follow Up Of Thyroid Nodules

    Thyroid Nodules – When to Worry? (Signs your nodule could be something more)

    For patients that do not need surgery , discuss with your clinician the best surveillance schedule for your nodules.

    This will vary depending on if you had a biopsy, how long you have had the nodules, and what they look like on ultrasound. For the most part, you should not need a repeat biopsy if you had a benign biopsy once, and you should not have to follow thyroid nodules yearly for the rest of your life.

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    Ultrasound Criteria May Allow For More Selective Thyroid Biopsies

    Ultrasound criteria may help determine when a thyroid nodule should be biopsied and help reduce the number of unnecessary procedures, according to a retrospective case-control study in JAMA Internal Medicine.

    Current guidelines recommend biopsy of many thyroid nodules > 5 to 15 mm in diameter. However, the new findings suggest the presence of two of three abnormal characteristics found on ultrasound may further refine the decision for biopsy.

    Compared with other existing guidelines, many of which are complicated to apply, following these simple, evidence-based guidelines would substantially decrease the number of unnecessary thyroid biopsies in the United States, said lead author Rebecca Smith-Bindman, MD, Professor, Department of Radiology and Biomedical Imaging, University of California San Francisco School of Medicine. Right now, were doing far too many thyroid biopsies in patients who are really at very low risk of having thyroid cancer, she said.

    Ultrasound is by far the best way to evaluate the thyroid, Dr. Alexander said. For every patient, we want to use historical data and physical examination, ultrasound and imaging data, while also recognizing that fine needle aspiration is an extremely low risk, minimally invasive procedure that can provide a lot of very useful information, he said.

    Hello Alapahmy Name Is Alla

    Hello Alapah,

    My name is Alla and I was diagnosed with PTC few months ago, I am scheduled to have surgery on 9/2, however, I did do BRAF mutation mark before surgery and was positive. Did you have BRAF done for you? How big was you nodule? How long has it been since you had your surgery? My understanding since I have BRAF my form as well more aggresive and can reccure between 1-5 years. Sorry to ask you all these questions, but I am very scared for my upcoming surgery, thinking am I better off leave it the way it is or fight for my life after they remove it and I have less chances of survival?

    July 22, 2020Cancer, Primary Care

    The American Cancer Society estimates that in 2020, approximately 52,890 new cases of thyroid cancer will be diagnosed and that there will be approximately 2,180 deaths from thyroid cancer. While most thyroid cancer is found by accident, there are warning signs you should be aware of for a better chance of early detection.

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    What Happens After A Fine Needle Aspiration Biopsy

    Most people will be able to resume their normal activities right away. You can remove your bandage within a few hours.

    The site of the biopsy might be sore for a day or two after the procedure. You can take over-the-counter pain medicines if you need to. Follow any other specific instructions that your healthcare provider gives you.

    It may take several days to get your test results from the pathology lab. Ask your healthcare provider when you can expect to get your results back.

    If your thyroid nodule is not cancer, you might not need any further treatment. Your provider may want to monitor your nodule, though, and you might need another biopsy in the future. In some cases, your healthcare provider may offer thyroid hormone pills. These can sometimes decrease the likelihood of nodules growing back.

    You will probably need surgical treatment if your nodule appears cancerous. Luckily, most thyroid cancers are curable.

    Sometimes, the pathologist cannot determine for sure whether your nodule is cancer. In this case, your healthcare provider might recommend a repeat biopsy or surgery. Whatever your test results, you can work with your healthcare provider to develop the best possible treatment plan for you.

    What Do The Results Of Tpo Antibodies Test Mean

    Recommendations on thyroid nodule biopsy based on revised ...

    The TPO antibodies test results may show one of the following options:

    • Negative as you can already conclude negative TPO antibodies test result indicates that no thyroid antibodies were found. This result also implies that thyroid problems and symptoms a patient experiences are not caused by an autoimmune condition
    • Positive antibodies to TPO and/or Tg this result indicate a patient may have Hashimotos thyroiditis
    • Positive antibodies to TPO and/or TSH may indicate the presence of Graves disease

    The higher the level of antibodies, the more likely it is that a patient has an autoimmune disease of the thyroid e.g., Hashimotos or Graves disease. Blood test results for TPO antibodies are positive in 95% of patients with Hashimotos thyroiditis and in 50% to 80% of people with Graves disease.

    When it comes to TPOAbs, the reference value is < 9.0 IU/ml . Values above 9.0 are typically associated with autoimmune thyroid disease, but elevations are also observed in some other autoimmune conditions. The most commonly mentioned TPOAb reference range is less than 35 IU/ml.

    The presence of TPOAbs in patients with subclinical hypothyroidism predicts an elevated risk of overt hypothyroidism. Moreover, this also shows that those patients could be at a higher risk of developing other autoimmune conditions like type 1 diabetes.

    As mentioned above in the article, some people may be positive to TPO antibodies, but they do not have a thyroid condition.

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    When To Be More Proactive

    Although most thyroid nodules are benign, some can harbor thyroid cancer. And some types of thyroid cancer are more aggressive than others. You should be more proactive in seeing an endocrinologist if you have any of the following symptoms:

    • A lump in your neck that appears to be growing
    • Swelling or pain in the neck
    • Hoarse voice
    • Persistent cough
    • Trouble breathing or swallowing

    Also see an endocrinologist if you have been diagnosed with a thyroid nodule and have any of the following risk factors for thyroid cancer:

    • An immediate family member who was diagnosed with thyroid cancer
    • Any kind of radiation exposure, especially to the head and neck area

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    Waiting For Thyroid Biopsy Results And Feeling Anxious

    Hello everyone,

    This is my first post in here so Ill explain a little about my background to start off. Im 29 years old, wife to a wonderful husband and mother of 1 little boy who will be 2 in a few weeks and is my whole world.

    I first noticed a lump on my throat back in January and went to my Dr who took bloods and sent me for an ultrasound scan. The bloods came back and showed slightly lower than average levels of T4. The ultrasound scan showed several nodules on my thyroid, some were fluid filled cysts, others were solid and more of a concern.

    From then I was referred to an ENT consultant for a second ultrasound which showed one particular solid mass that was a concern as well as the cysts they had previously seen. At that appointment they took a couple of different biopsies from the lump and also drained all the fluid from the cysts so now Ive just beven given an appointment for 4 weeks time to come back for the results.

    Im not sure at this stage how likely it is to be cancer/what they will do about the lump etc if its not and I really feel so in the dark about it all. We are going on a family holiday in a couple of weeks and I feel like all Ill be doing is worrying about this so it would be lovely to be able to chat to others that are/have been in a similar situation to me.

    Thank you for taking the time to read my post

    Emma x

    Do let us know how you get on.

    Kind regards,

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    Is It Necessary To Get A Biopsy For Thyroid Nodules

    From time to time Ill receive a question from someone who has one or more thyroid nodules about whether or not they should get a biopsy. Of course their main concern is that the thyroid nodule will be cancerous. Just like any other procedure, everything comes down to risks vs. benefits. And while there is a small risk with obtaining a biopsy, it still is an invasive procedure, and it doesnt always rule out a malignancy. On the other hand, there is also a risk of not getting a biopsy and then finding out at a later time that you have a cancerous nodule. In this article I will give my opinion about whether a biopsy is necessary.

    Before I talk about whether getting a biopsy is necessary, lets first talk about thyroid cancer. There are a few different types of thyroid cancer, including papillary thyroid cancer, follicular thyroid cancer, medullary thyroid cancer, and anaplastic thyroid cancer. Im not going to discuss the different types, but if you want more information I would recommend taking a look at the article Thyroid Cancer Types, Stages and Treatment Overview. Of the four different types of cancer I listed, papillary cancer is the most common type of cancer, with follicular cancer being the second most common. The chances of long-term survival is high with the first three types of cancers, whereas anaplastic is more aggressive.

    Fine Needle Aspiration vs. Core Needle Biopsy

    When Should Someone Receive A Thyroid Biopsy?

    1) Microcalcifications of the thyroid nodule


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