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What Is Thyroid Peroxidase Tpo Ab

Results For This Questionfeedbackzrt Thyroid Peroxidase Antibodies Blood Home

What are TPO antibodies?

ZRT Thyroid Peroxidase Antibodies Blood Home Thyroid Test Kit.This at-home anti TPO test allows you to measure the presence of TPO in your blood to help detect the presence of an auto-immune disease.Due to state law,we cannot ship this product to NY State. results for this questionWhat is a thyroglobulin assay?What is a thyroglobulin assay?The most important characteristic of a Thyroglobulin assay is how reliably the assay discriminates between the assays functional sensitivity and the lower limit of the normal reference range signaling residual thyroid tissue after thyroid ablation.Thyroglobulin aids in monitoring patients who have undergone thyroidectomy.Thyroid Assay Menu – Siemens Healthineers USA

Human Thyroid Peroxidase Iqelisa Kit

The Human Thyroid Peroxidase IQELISA kit is an ultrasensitive ELISA utilizing qPCR detection for 10X more sensitivity with 10X less sample.Human Thyroid peroxidase / TPO ELISA Kit – Assay GenieThe below protocol is a sample protocol for Human Thyroid peroxidase / TPO ELISA Kit using a biotinylated detection antibody and streptavidin-HRP.Sandwich ELISAs allow for the detection and quantification of an analyte in a sample by using known analyte concentrations as standards and plotting absorbance of known concentrations vs known

How Often Should You Test Your Thyroid Antibodies

I often hear from readers who say that their doctors refuse to retest their thyroid antibodies, stating that once a person is thyroid antibody positive, they will always be positive, so retesting the antibodies is useless. I disagree. Tracking your thyroid antibodies can give you an idea of how aggressive the attack is on your thyroid gland. While other lab markers and symptoms should be considered, generally, a lower thyroid antibody number indicates that your condition is improving, while a higher antibody number may indicate that you are having a flare-up or that your condition is worsening.

Tracking antibodies can give you an idea of whether the interventions youre utilizing are working, i.e. is your change in diet leading to an improvement in your condition?

When implementing active interventions, you can check antibody levels every 1-3 months to see a trend; however, it will take anywhere from 3 months to 2 years to see the full impact of an intervention.

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What Do The Results Of Tpo Antibodies Test Mean

The TPO antibodies test results may show one of the following options:

  • Negative as you can already conclude negative TPO antibodies test result indicates that no thyroid antibodies were found. This result also implies that thyroid problems and symptoms a patient experiences are not caused by an autoimmune condition
  • Positive antibodies to TPO and/or Tg this result indicate a patient may have Hashimotos thyroiditis
  • Positive antibodies to TPO and/or TSH may indicate the presence of Graves disease

The higher the level of antibodies, the more likely it is that a patient has an autoimmune disease of the thyroid e.g., Hashimoto’s or Graves’ disease. Blood test results for TPO antibodies are positive in 95% of patients with Hashimotos thyroiditis and in 50% to 80% of people with Graves disease.

When it comes to TPOAbs, the reference value is <9.0 IU/ml . Values above 9.0 are typically associated with autoimmune thyroid disease, but elevations are also observed in some other autoimmune conditions. The most commonly mentioned TPOAb reference range is less than 35 IU/ml.

The presence of TPOAbs in patients with subclinical hypothyroidism predicts an elevated risk of overt hypothyroidism. Moreover, this also shows that those patients could be at a higher risk of developing other autoimmune conditions like type 1 diabetes.

As mentioned above in the article, some people may be positive to TPO antibodies, but they do not have a thyroid condition.

How To Lower Thyroid Antibodies


However, using thyroid medication has its limitations and practice shows that most patients get their antibodies lowered only partially. There is a holistic nutritional approach to Hashimotos disease that has demonstrated great results in lowering thyroid antibodies because it looks for factors that cause them initially.

Hashimotos disease occurs as a result of complex interactions between genetic and environmental factors. According to the;recent research conducted and published by Prof. Fasano, there is a new factor that plays the key role in the initiation of the autoimmunity.

Increased intestinal permeability or leaky gut syndrome is a condition when intestinal gut walls lose their protective effect and let through the antigens that cause the overreaction of the immune system. Leaky gut is a reversiblecondition and is one of the factors that;should be;addressed first.

There are many scientific publications that support this treatment approach and the idea that

Hypothyroidism caused by Hashimotos disease is reversible in some cases

Since most environmental triggers of autoimmune overreaction are dietary, identifying and removing these factors should be the next step. This strategy has not only has promising results in dampening the autoimmune reaction but also in lowering thyroid antibodies levels.

There are many other dietary factors that can trigger Hashimotos disease. But we are all different and what works for some people may not work for you and vice versa.

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Is It Possible To Reduce Thyroid Peroxidase Antibodies If They Are Elevated


And this might just be the most important part of this article.;

After all, if you know that TPO antibodies are causing problems in your body, doesnt it make sense to try and do something about them?

Of course!

But heres the problem:

From the perspective of your doctor, theres nothing that can be done about elevated thyroid peroxidase antibodies.;

Doctors take what is called the sit and wait approach to managing people who have elevated thyroid antibodies.;

They sit and wait until your own body damages the thyroid gland to the point that you need prescription medication.;

Just because your doctor doesnt have any medical treatment options for you doesnt mean you cant do anything, though!

Seeing a doctor is important, for sure, but when it comes to managing your thyroid antibodies you are probably going to be on your own.;

It may sound difficult but it actually isnt.;

Making some changes to your lifestyle can have an impact on your immune system and thyroid health and this may directly help your antibodies.;

Doing things like changing the food that you eat can have a huge impact on your antibody levels.;

Avoiding foods that are known to be inflammatory is a great place to start.;

Eating foods that are known to possess natural anti-oxidants and plant-based nutrients is also a wise decision.;

You can also focus on improving your lifestyle.;

And guess what?

You dont really need a doctor to tell you that eating fruits and vegetables is a good thing, right?

Cited By 330publish Year 1998author Normand Desprsandrew Mgrantestimated Reading Time 9 Minsevaluation Of Chemiluminescence Immunoassays For

Abstract.The chemiluminescence assays for detection of autoantibodies to thyroid peroxidase and thyroglobulin implemented on the IMMULITE 2000 system were evaluated.These were immunometric assays with antigen-coated beads and monoclonal murine anti-IgG antibodies conjugated with alkaline phosphatase.Precision was satisfactory with an intraassayCited by 5Publish Year 2017Author Eijun Nishihara,Nobuyuki Amino,Takumi Kudo,Mitsuru Ito,Shuji Fukata,Mitsushige Nishikawa,HirotThyroid Peroxidase IgG ELISA Kit – Novus BiologicalsThe Thyroid Peroxidase IgG ELISA Kit is intended for the detection of IgG antibody to Thyroid Peroxidase in human serum or plasma.Background Thyroid peroxidase ,is the major autoantigen in the thyroid microsomal antigen particle.

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Thyroid Peroxidase Igg Elisa Kit

The Thyroid Peroxidase IgG ELISA Kit is intended for the detection of IgG antibody to Thyroid Peroxidase in human serum or plasma.Background Thyroid peroxidase ,is the major autoantigen in the thyroid microsomal antigen particle.Thyroid Peroxidase IgG GenWay Biotech,Inc.ELISAThe GenWay,Inc.Thyroid Peroxidase IgG ELISA Kit is intended for the detection of IgG antibody to Thyroid Peroxidase in human serum or plasma.SUMMARY AND EXPLANATION Thyroid peroxidase ,is the major autoantigen in the thyroid

What Does Your Thea Score Mean

Thyroid peroxidase antibodies/thyroid peroxidase

Ideally, we want a THEA score of 0. That is only possible without any genetic predispositions. With a genetic predisposition, the lowest score will always be a 2.

Low risk is considered in the 0-7 range. This means they are at a low risk of developing Hashimotos, or that their Hashimotos is not super aggressive at this point. Nonetheless, they are at risk. For a person with a genetic predisposition, with no other points lets say they score a 2 they still have a 1.6 percent chance of being hypothyroid within 5 years. Keep in mind that if this same individual experiences more triggers, that will contribute to the disease progression.

The higher the score, the higher the aggressiveness rating, and the higher the chance of a person becoming hypothyroid within 5 years.

If we look at a score from 16-21, we know that the aggressiveness of the condition is very high and that they have about a 86 percent chance of becoming hypothyroid within 5 years. As we know that hypothyroidism is Stage 4 of Hashimotos, while other autoimmune conditions occur in Stage 5, higher thyroid antibodies may also predict a faster progression to other types of autoimmune conditions.

What I hope for with my clients is that they can reduce their risk and eliminate their symptoms. And the best way to reduce the THEA score early-on is to reduce thyroid antibodies.

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Thyroid Microsomal 1422z 10

thyroid hormones.The thyroid microsomal antigen has been shown to be the enzyme thyroid peroxidase .Antibodies to thyroglobulin and/or microsomal antigen are present in most patients with goitrous thyroiditis ,atrophic thyroiditis and about 70-90% of Graves disease .Thyroid Peroxidase – an overview ScienceDirect TopicsAlan Lap-Yin Pang,Wai-Yee Chan,in Essential Concepts in Molecular Pathology,2010.Thyroid Peroxidase.Thyroid peroxidase is a key enzyme in thyroid hormone biosynthesis.It catalyzes both iodination and coupling of iodotyrosine residues in TG.Human TPO is located on chromosome 2p25,with 17 exons.The mRNA is about 3 kb encoding a thyroid-specific glycosylated hemoprotein

So Whats Your Thea Score

Do you know what yours is? If not, do a quick calculation now by taking the assessment it is easy to do. Assign points as per the chart based on your TSH, TPO antibodies and family background. Again, low risk is considered in the 0-7 range. This means the Hashimotos is or would not be super aggressive. But, you are still at risk.

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Causes Of Hashimotos Thyroiditis

Doctors aren’t entirely sure why the immune system, which is supposed to defend the body from harmful viruses and bacteria, sometimes turns against the body’s healthy tissues.

Some scientists think a virus or bacterium might trigger the response, while others believe it may involve a genetic flaw. A combination of factorsâincluding heredity, sex, and ageâmay determine your likelihood of developing the disorder.

Genetic predisposition

Researchers estimate that 70%â80% of autoimmune thyroid disease susceptibility is from a family history of autoimmune disease.


Pregnancy puts metabolic stress on a woman. The thyroid undergoes noticeable modifications to cope. These changes are typically reversible after birth, though pregnancy can sometimes be a trigger for postpartum thyroiditis. Postpartum thyroiditis is a condition in which the thyroid becomes inflamed within the first year after birth. In most cases, postpartum thyroiditis is limiting to weeks or months after delivery but occasionally develops into Hashimoto’s disease.

Other hormonal events

Hashimoto’s is seven times more likely to occur in women than men. Hormonal events like puberty, pregnancy, or menopause may contribute to the development of Hashimoto’s.


It is not uncommon for someone with one autoimmune condition to have another like celiac disease, type one diabetes, rheumatoid arthritis, or lupus. This condition of have two or more autoimmune disorders is polyautoimmunity.

What Do The Results Mean

rate (%) of thyroid peroxidase antibody (TPO

Your results may show one of the following:

  • Negative: no thyroid antibodies were found. This means your thyroid symptoms are probably not caused by an autoimmune disease.
  • Positive: antibodies to TPO and/or Tg were found. This may mean you have Hashimoto disease. Most people with Hashimoto disease have high levels of one or both of these types of antibodies.
  • Positive: antibodies to TPO and/or TSH receptor were found. This may mean you have Grave’s disease.

The more thyroid antibodies you have, the more likely it is that you have an autoimmune disorder of the thyroid. If you are diagnosed with Hashimoto disease or Grave’s disease, there are medicines you can take to manage your condition.

Learn more about laboratory tests, reference ranges, and understanding results.

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Autoimmune Antibodies And Thyroid Disease

Antibodies are proteins produced by your body to help protect you against infections. They can, however, mistakenly attack your own tissues, causing illness. The consequence is described as an autoimmune disease, and some thyroid conditions are caused by this immune system dysfunction.

There are several types of thyroid antibodies, and each one attacks a different target in the thyroid hormone production process, ultimately causing thyroid disease.

The most common thyroid antibodies are:

  • Anti-thyroperoxidase antibodies
  • Thyroid;stimulating hormone receptor; antibodies
  • Anti-thyroglobulin ;antibodies

Do Antibody Numbers Matter

Some clinicians will say that once you have thyroid antibodies, you will always have thyroid antibodies, so the actual number doesnt matter, as the antibodies can randomly fluctuate. I respectfully disagree. Antibodies fluctuate in response to triggers , and in my exhaustive experience, they can be an incredibly helpful marker for tracking disease progression. That said, they should not be the only marker. We also want to look at your overall health and the big picture are you feeling better or worse?

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What Number Is Considered Remission

Remission to me is a journey, not necessarily a destination. While researchers have labeled thyroid antibodies under 100 IU/mL as remission status, and thyroid antibodies above 500 IU/mL as aggressive, I would again caution to look at the big picture.

Remission is not the same as a cure, rather, remission is a respite from the disease, a reduction in the expression of the condition as well as a reduction in symptoms.

The definition for remission will thus vary with each person. Where were you when you got started on your journey?

If you started with thyroid antibodies in the 5000 IU/ml range and 10+ symptoms, improving your health to a point where your antibodies are 1000 IU/ml, and you only have 5 symptoms, may be your remission.

If, however, you started with antibodies in the 200 IU/ml range, and only had 3 symptoms to begin with, thyroid antibodies of 1000 IU/ml and 5 symptoms may be an exacerbation or worsening of the condition for you.

Thus, the goal of remission is for you to work on improving your health, and every small change that I recommend will hopefully result in an improvement for you. And yes, in some cases, a complete remission is possible, where you no longer test positive for any thyroid antibodies, dont have a single symptom, and there is no evidence of damage to your thyroid gland.

What Your Tpo Antibodies Test Results Mean

Thyroid Peroxidase Antibody Test | Anti TPO Test

The normal range for TPO Antibodies is less than 35 IU/mL.

A null to minimal TPO Antibody test means that your blood does not contain TPO antibodies. This normally insinuates that the causes of your thyroid symptoms are not due to an auto-immune disease. However, if these conditions are suspected; then, a recurring test may be recommended.

When the levels are mildly elevated, this can be caused by many thyroid conditions like thyroid cancer, type-1 diabetes, rheumatoid arthritis, as well as auto-immune collagen vascular disease.

High levels of TPO Antibodies are usually caused by an autoimmune disease like the Hashimoto Thyroiditis, Graves Disease, pernicious anemia, lupus and rheumatoid arthritis. It has been reported that almost 3% of people who have a positive TPO test result do not show any symptom.

If levels are high in a pregnant woman, this may lead to higher risks of developing hypothyroidism or hyperthyroidism in the newborn baby.

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Stage : The Breakdown Of The Immune Tolerance

In the second stage, you start seeing the breakdown of the thyroids immune tolerance, and the person will start to have a white blood cell infiltration into the thyroid gland. Some of these immune cells are going to start grouping there. This;is when we will also start seeing elevated thyroid antibodies. This stage can go on for many years a decade or more before a person moves on to stage 3 or 4, when we start to actually see symptoms and changes in thyroid function.

Thea Score: Assessing Your Risk For Hypothyroidism

Once you have your lab results in hand, there is a great tool that your clinician can use to help determine the aggressiveness of your condition. The Thyroid Event Amsterdam Score is a score that can help assess your risk of progression into hypothyroidism.

The THEA score is used to help estimate the risk of developing hypothyroidism within five years in people who have TPO antibodies, and can also help estimate the risk for those who have relatives with thyroid diseases.

Please note that thyroid antibodies make a very big contribution to the total THEA score.

How does THEA work? It applies a certain amount of points towards different measures. These measures consist of genetic predisposition as well as lab test results. Ive included a chart that shows you how the scoring is made.

Genetic predisposition: We know there is a genetic component to developing Hashimotos, and it tends to run in families. So, if you have relatives with Hashimotos, that increases your risk. And if you have been diagnosed with thyroid disease, theres a greater chance that a loved one like your child, parent or sibling may be at risk as well.

Hashimotos can occur in two varieties: an organ wasting form associated with HLA-DR3 gene inheritance, and an enlarged thyroid form through HLA-DR5 inheritance.

People with these genes and who have a relative with Hashimotos would get points. Someone with multiple relatives with Hashimotos would get additional points.

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Clinical Information Discusses Physiology Pathophysiology And General Clinical Aspects As They Relate To A Laboratory Test

Thyroperoxidase is an enzyme involved in thyroid hormone synthesis, catalyzing the oxidation of iodide on tyrosine residues in thyroglobulin for the synthesis of triiodothyronine and thyroxine . TPO is a membrane-associated hemoglycoprotein expressed only in thyrocytes and is one of the most important thyroid gland antigens.

Disorders of the thyroid gland are frequently caused by autoimmune mechanisms with the production of autoantibodies. Anti-TPO antibodies activate complement and are thought to be significantly involved in thyroid dysfunction and the pathogenesis of hypothyroidism.

The determination of TPO antibody levels is the most sensitive test for detecting autoimmune thyroid disease and detectable concentrations of anti-TPO antibodies are observed in most patients with these disorders. The highest TPO antibody levels are observed in patients suffering from Hashimoto thyroiditis. In this disease, the prevalence of TPO antibodies is about 90% of cases, confirming the autoimmune origin of the disease. These autoantibodies also frequently occur in the course of Graves disease.

In patients with subclinical hypothyroidism, the presence of TPO antibodies is associated with an increased risk of developing overt hypothyroidism. Many clinical endocrinologists use the TPO antibody test as a diagnostic tool in deciding whether to treat a patient with subclinical hypothyroidism, and Mayo Clinic Laboratories endorses this practice.


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