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What Does High Anti Thyroid Peroxidase Mean

What Does Extremely High Thyroid Peroxidase Mean

Thyroid peroxidase antibodies/thyroid peroxidase

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Treatment Options For Patients With High Anti

So what are you supposed to do if you have high anti-TPO antibody levels?

It turns out that there are several things you can do to lower these antibody levels.

The treatment is especially important because your physician may take the “wait and see” approach to treatment.

Basically many doctors may not even try to treat your antibody levels until they have caused glandular damage and thyroid hormone replacement is required.

Luckily there are several therapies that you can do to help reduce inflammation and autoimmunity.

Note: for best results, it’s wise to use a combination of these therapies and stack them together. If you take just 1-2 supplements, for instance, you will be limiting your progress.

#1. Supplements

We’ve already discussed how certain nutrient deficiencies can predispose to developing autoimmune diseases.

This should give you an idea of the importance of nutrients and supplements in treating these conditions.

Now we need to discuss how certain nutrients can reduce inflammation and have even been shown to lower TPO antibody levels.

Supplements to reduce inflammation and autoimmunity:

Supplements to improve thyroid function:

You can also check out a more detailed guide on which supplements to take if you are hypothyroid here and which supplements to take if you have Hashimoto’s here.

#2. Medications

In addition to using supplements, there are some medications that can be used to help reduce inflammation.

#3. Hormones

#4. Diet

#5. Avoid endocrine disruptors

How To Heal Your Thyroid

Based on the results of the TPOAbs test, the doctor will recommend certain treatment measures if necessary.

However, there are many things you can do on your own in order to prevent or lower the levels of antibodies. These measures can help delay progression or aid management of autoimmune thyroid conditions. Below, you can see some useful suggestions:

  • Modify your diet the first and most important thing you can do to lower levels of TPO antibodies is to modify your diet. Make sure to lower or avoid intake of heavily processed and refined foods, GMO foods, and foods laden with thickening agents, artificial sweeteners, thickening agents, food dyes, among others. Instead, try to include organic fruits and vegetables into your diet and other foods that are rich in nutrients and with amazing anti-inflammatory activity. You also need to consume fiber-rich foods which are beneficial for the digestive system i.e., your gut. Additionally, your diet also needs protein which assists in the repair of tissues in the body, participates in the transport of thyroid hormones throughout the body

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You Must Reduce Elevated Tpo Antibodies Down To The Normal Reference Range To Prevent Hypothyroidism

If a recent lab test has shown that you have elevated thyroid antibodies, your next question might be, How can I bring them down to normal levels?

When it comes to thyroid antibodies, striving for perfection may be overrated. Lets talk about what level of antibodies you should aim for and how to reduce them.

Are Extremely High Thyroid Peroxidase Antibodies Dangerous


The real question to answer here is whether or not the absolute level of thyroid peroxidase antibodies tracks with disease severity.

In other words, does having a higher level of antibodies mean that your disease is more severe and more dangerous than someone with fewer antibodies?

The answer is not as clear cut as you might think but it is probably the case that the higher your antibody levels are the more severe and more dangerous your disease state.

Logically, this makes sense.

If you have more antibodies floating around in your bloodstream then there will be more damage done to your thyroid gland over a shorter period of time.

More antibodies mean more inflammation which means more thyroid gland which means more symptoms.

Evidence that supports this idea is in the case of seronegative Hashimoto’s.

Some people have Hashimoto’s with negative antibody levels, otherwise known as seronegative Hashimoto’s.

Patients with this condition experience much more mild side effects compared to patients who have high levels of antibodies in their blood.

Having said that, the presence of high thyroid peroxidase antibodies does NOT necessarily mean that your disease state is more difficult to treat.

Put another way, the presence of extremely high antibodies is worrisome but it doesn’t mean that you can’t do something about it .

We also know that thyroid antibodies play some role in the development of certain cancers .

Read Also: Hypothyroidism Double Chin

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The Connection Between Thyroid Peroxidase Antibodies Hashimoto’s And Graves’ Disease

Does the presence of elevated thyroid peroxidase antibodies guarantee that you have Hashimoto’s?

Definitely not!

Elevated TPO antibodies are seen in 90-95% of patients with Hashimoto’s and 50 to 80% of patients who have Graves’ disease.

The best way to determine what your antibodies mean for you is to look at your thyroid lab tests, your thyroid peroxidase antibodies, and your symptoms:

  • The presence of thyroid peroxidase antibodies with a LOW TSH and symptoms of hyperthyroidism point towards a diagnosis of Graves’ disease
  • The presence of thyroid peroxidase antibodies with a HIGH TSH and the symptoms of hypothyroidism point towards a diagnosis of Hashimoto’s thyroiditis
  • The presence of thyroid peroxidase antibodies with a normal TSH and no symptoms predicts an increased risk of developing a thyroid condition in the future
  • The absence of thyroid peroxidase antibodies does not rule out hyperthyroidism or hypothyroidism as both of these conditions can be caused by other conditions

Recommended Reading: Double Chin Thyroid

Causes Of Hashimotos Thyroiditis

Doctors aren’t entirely sure why the immune system, which is supposed to defend the body from harmful viruses and bacteria, sometimes turns against the body’s healthy tissues.

Some scientists think a virus or bacterium might trigger the response, while others believe it may involve a genetic flaw. A combination of factorsâincluding heredity, sex, and ageâmay determine your likelihood of developing the disorder.

Genetic predisposition

Researchers estimate that 70%â80% of autoimmune thyroid disease susceptibility is from a family history of autoimmune disease.


Pregnancy puts metabolic stress on a woman. The thyroid undergoes noticeable modifications to cope. These changes are typically reversible after birth, though pregnancy can sometimes be a trigger for postpartum thyroiditis. Postpartum thyroiditis is a condition in which the thyroid becomes inflamed within the first year after birth. In most cases, postpartum thyroiditis is limiting to weeks or months after delivery but occasionally develops into Hashimoto’s disease.

Other hormonal events

Hashimoto’s is seven times more likely to occur in women than men. Hormonal events like puberty, pregnancy, or menopause may contribute to the development of Hashimoto’s.


It is not uncommon for someone with one autoimmune condition to have another like celiac disease, type one diabetes, rheumatoid arthritis, or lupus. This condition of have two or more autoimmune disorders is polyautoimmunity.

What Is Hashimotos Thyroiditis

Thyroid Peroxidase Antibody Test | Anti TPO Test

Hashimoto’s thyroiditis is an autoimmune disorder that damages the thyroid gland. Autoimmunity occurs when immune cells attack healthy tissue instead of protecting it, leading to chronic inflammation.

In Hashimoto’s thyroiditis, immune cells mistakenly attack the healthy thyroid tissue, causing inflammation of the thyroid. This damage can eventually lead to inadequate thyroid hormone production. Without enough thyroid hormones for your body to function correctly, you develop hypothyroidism.

Hashimoto’s thyroiditis is the leading cause of hypothyroidism in the United States, affecting roughly 5% of the population.

Also Check: Is Apple Cider Vinegar Good For Your Thyroid

What Does A Positive Thyroid Antibody Test Mean

Thyroid Antibody Tests. For example, positive anti-thyroid peroxidase and/or anti-thyroglobulin antibodies in a patient with hypothyroidism make a diagnosis of Hashimotos thyroiditis. If the thyroid antibodies are positive in a hyperthyroid patient, the most likely diagnosis is autoimmune thyroid disease.

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The Importance Of Thyroid Antibodies Even In The Absence Of Hypothyroidism

Thyroid antibodies have been connected to many symptoms even in the absence of hypothyroidism. When people are in stage 2 and they have thyroid antibodies, they may start to exhibit a whole bunch of different non-specific symptoms like fatigue, anxiety, stress, miscarriages, weight gain, and just feeling unwell.

Without verifying the presence of thyroid antibodies, these types of symptoms may not be associated with developing thyroid disease, and they may end up being misdiagnosed as other things such as anxiety, fatigue , depression, menopause, or even hypochondria. I have personally seen a number of clients who were diagnosed with depression and even bipolar disease as a result of being in stage 2 and already having elevated thyroid antibodies for years.

Remember, if these antibodies go unchecked, we are going to potentially start seeing a progression into stage 3, where we see subclinical hypothyroidism, stage 4 where we start seeing changes in TSH, and stage 5 which may include the progression of other autoimmune conditions.

Note that a small number of antibodies may be present in normal individuals without thyroid disease. According to UpToDate, roughly 5-27 percent of the general population will test for extremely low levels of antibodies . But, when you find elevated thyroid antibodies outside of this range, that is an indicator that the immune system is targeting the thyroid gland for destruction.

Elevated Thyroid Stimulating Immunoglobulins

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If you have elevated TSI antibodies, even if your TSH level is normal, you most likely have Graves disease, an autoimmune condition. In Graves disease, the TSI antibodies cause your thyroid gland to make too much thyroid hormone. As TSI antibodies cause overproduction of thyroid hormone, a TSH in the reference range drops, and you can become hyperthyroid fairly quickly.

What should you do?

If you have thyroid symptoms, but your TSH test result falls within the reference range, an important next step is to request that your doctor order thyroid antibody tests. If your symptoms suggest hypothyroidismfatigue, weight gain, depression, hair lossyou should request a TPO antibody test. If your symptoms suggest hyperthyroidismanxiety, insomnia, weight loss, diarrhea, elevated heart rate/blood pressureyou should request a TSI antibody test.

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What Is Being Tested

Thyroid autoantibodies are antibodies that develop when a persons immune system mistakenly targets components of the thyroid gland or thyroid proteins, leading to chronic inflammation of the thyroid , tissue damage, and/or disruption of thyroid function. Laboratory tests detect the presence and measure the quantity of specific thyroid autoantibodies in the blood.

The thyroid is a small, butterfly-shaped gland that

Thyroid autoantibodies are antibodies that develop when a persons immune system mistakenly targets components of the thyroid gland or thyroid proteins, leading to chronic inflammation of the thyroid , tissue damage, and/or disruption of thyroid function. Laboratory tests detect the presence and measure the quantity of specific thyroid autoantibodies in the blood.

The thyroid is a small, butterfly-shaped gland that lies flat against the windpipe in the throat. The primary hormones that it produces, thyroxine and triiodothyronine , are vital in helping to regulate the rate at which the body uses energy . The body uses a feedback system in which thyroid stimulating hormone stimulates the thyroid to produce T4 and T3 as needed. This system helps maintain a relatively stable amount of the thyroid hormones in the blood. When thyroid antibodies interfere with this process, they can lead to chronic conditions and autoimmune disorders associated with hypothyroidism or hyperthyroidism, such as Graves disease or Hashimoto thyroiditis.

Thyroid antibody tests include:

Conditions Associated With High Thyroid Peroxidase Antibodies

What does it mean if you have thyroid peroxidase antibodies floating around in your blood?

Well, it can mean several things:

  • It may be a marker for the autoimmune disease known as Hashimoto’s thyroiditis.
  • It may also be a marker for another autoimmune disease of the thyroid gland known as Graves’ disease .
  • It may be a transient thing that may eventually go away on its own ).

The presence of thyroid peroxidase antibodies is never “normal” but it doesn’t always guarantee a poor outcome.

For instance, as I mentioned above, some people see elevated antibodies during pregnancy which then fall after birth.

The significance of thyroid peroxidase in this exact setting is not well understood but it does give some hope that not every situation of elevated antibodies points to autoimmune disease.

Why would you want to check your thyroid peroxidase antibodies?

Your doctor can use this test in a number of useful ways:

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What Are The Thyroid Antibodies That Need To Be Tested

There are three main types of antibodies in Hashimotos that are potentially going to be present. Two of them are created by the immune system to target the thyroid gland as if it were a foreign invader like a pathogen, and those are Thyroid Peroxidase and Thyroglobulin antibodies.

80-90 percent of people with Hashimotos will haveeitherTPO or TG antibodies, or both. The more elevated the thyroid antibodies are, the greater the likelihood of developing overt hypothyroidism as well as possibly additional autoimmune conditions.

Where do these antibodies come from? The current scientific thinking is that activated B-cells in the thyroid gland and lymph nodes secrete these antibodies, and that they react solely as markers but dont necessary attack the thyroid gland themselves. They likely activate T-cells, which then do the actual damage on the thyroid gland.

The third type of thyroid antibodies is TSH-Receptor antibodies, including thyroid-stimulating immunoglobulin . This particular marker is elevated in more than 90 percent of people with Graves disease. TSH-R antibodies are also more common in people who have thyroid cancer.

Another TSH-R antibody is known as TSH-binding inhibiting immunoglobulin . This is elevated in > 50 percent of people with Graves disease.

Symptoms Associated With High Thyroid Peroxidase Antibodies

What are TPO antibodies?

Thyroid peroxidase antibodies typically do not cause any major symptoms by themselves.

They can sometimes be associated with minor symptoms including a minor decrease in energy, feeling run-down, or just feeling blah.

These symptoms occur as your body attempts to deal with the immune dysfunction present as well as minor changes to thyroid function.

Most of the major symptoms associated with TPO antibodies come from the direct damage to the thyroid gland.

Remember the war zone that I mentioned previously?

Inflammation and damage to the thyroid gland may result in changes to thyroid function and this change to thyroid function results in symptoms that are hard to miss.

These symptoms vary based on whether you have a diagnosis of HYPERthyroidism or HYPOthyroidism .

You can use your symptoms, in conjunction with your antibodies and thyroid lab tests, to see where you fit.

#1. Symptoms of Hashimotos Thyroiditis:

  • Fatigue

#3. You may be asymptomatic.

Dont forget that some people, especially those who are pregnant, may have no symptoms at all!

We dont know how many people fit into this category, though, because most people do not get tested for thyroid peroxidase antibodies unless they are feeling poorly at which point they can be diagnosed.

Its also possible to be asymptomatic in the early stages of your disease, especially if you catch it early enough.

Recommended Reading: Graves Disease After Total Thyroidectomy

What Is Graves Disease

Gravesâ disease is an immune system disorder that results in the overproduction of thyroid hormones . Although a number of disorders may result in hyperthyroidism, Gravesâ disease is a common cause.

Because thyroid hormones affect a number of different body systems, signs and symptoms associated with Gravesâ disease can be wide ranging and significantly influence your overall well-being. Although Gravesâ disease may affect anyone, itâs more common among women and before the age of 40.

The primary treatment goals are to inhibit the overproduction of thyroid hormones and lessen the severity of symptoms.

Gravesâ disease causes

Gravesâ disease is caused by a malfunction in the bodyâs disease-fighting immune system, although the exact reason why this happens is still unknown.

One normal immune system response is the production of antibodies designed to target a specific virus, bacterium or other foreign substance. In Gravesâ disease â for reasons that arenât well understood â the body produces an antibody to one part of the cells in the thyroid gland, a hormone-producing gland in the neck.

Normally, thyroid function is regulated by a hormone released by a tiny gland at the base of the brain . The antibody associated with Gravesâ disease â thyrotropin receptor antibody â acts like the regulatory pituitary hormone. That means that TRAb overrides the normal regulation of the thyroid, causing an overproduction of thyroid hormones .

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